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Article

ZFYVE19 deficiency: a ciliopathy involving failure of cell division, with cell death

30 May 2024

Abstract excerpt

Background and aims Variants in ZFYVE19 underlie a disorder characterised by progressive portal fibrosis, portal hypertension and eventual liver decompensation. We aim to create an animal model to elucidate the pathogenic mechanism. Methods Zfyve19 knockout (Zfyve19−/− ) mice were generated and exposed to different liver toxins. Their livers were characterised at the tissue, cellular and molecular levels....

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PMID: 38816193
DOI: 10.1136/jmg-2023-109779

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