Article
Disturbances in hepatic cell-cycle regulation in mice with assembly-deficient keratins 8/18.
Hepatology (Baltimore, Md.) - 1 Dec 2001
Toivola D M, Nieminen M I, Hesse M, He T, Baribault H, Magin T M, Omary M B, Eriksson J E
Abstract excerpt
Simple epithelial tissues such as liver and pancreas express keratins 8 (K8) and 18 (K18) as their major intermediate filament proteins. K8 and K18 null mice and transgenic mice that express mutant K18 (K18C) manifest several hepatocyte abnormalities and demonstrate that K8/18 are important in ma...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
