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Article

Keratin overexpression levels correlate with the extent of spontaneous pancreatic injury.

The American journal of pathology - 1 Apr 2008

Toivola Diana M, Nakamichi Ikuo, Strnad Pavel, Michie Sara A, Ghori Nafisa, Harada Masaru, Zeh Karin, Oshima Robert G, Baribault Helene, Omary M Bishr

Abstract excerpt

Mutation of the adult hepatocyte keratins K8 and K18 predisposes to liver disease. In contrast, exocrine pancreas K8 and K18 are dispensable and are co-expressed with limited levels of membrane-proximal K19 and K20. Overexpression of mutant K18 or genetic ablation of K8 in mouse pancreas is well tolerated whereas overexpression of K8 causes spontaneous chronic pancreatitis. To better understand the effect of...

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Identifiers

PMID: 18349119
DOI: 10.2353/ajpath.2008.070830
PMCID: PMC2276414

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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