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Article

Keratin 18-deficiency results in steatohepatitis and liver tumors in old mice: A model of steatohepatitis-associated liver carcinogenesis.

Oncotarget - 8 Nov 2016

Bettermann Kira, Mehta Anita Kuldeep, Hofer Eva M, Wohlrab Christina, Golob-Schwarzl Nicole, Svendova Vendula, Schimek Michael G, Stumptner Cornelia, Thüringer Andrea, Speicher Michael R, Lackner Carolin, Zatloukal Kurt, Denk Helmut, Haybaeck Johannes

Abstract excerpt

Backround: Steatohepatitis (SH)-associated liver carcinogenesis is an increasingly important issue in clinical medicine. SH is morphologically characterized by steatosis, hepatocyte injury, ballooning, hepatocytic cytoplasmic inclusions termed Mallory-Denk bodies (MDBs), inflammation and fibrosis. RESULTS: 17-20-months-old Krt18-/- and Krt18+/- mice in contrast to wt mice spontaneously developed liver lesions...

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Identifiers

PMID: 27689336
DOI: 10.18632/oncotarget.12325
PMCID: PMC5341981

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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