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Article

Genetic background effects of keratin 8 and 18 in a DDC-induced hepatotoxicity and Mallory-Denk body formation mouse model.

Laboratory investigation; a journal of technical methods and pathology - 1 Jun 2012

Haybaeck Johannes, Stumptner Cornelia, Thueringer Andrea, Kolbe Thomas, Magin Thomas M, Hesse Michael, Fickert Peter, Tsybrovskyy Oleksiy, Müller Heimo, Trauner Michael, Zatloukal Kurt, Denk Helmut

Abstract excerpt

Keratin 8 (K8) and keratin 18 (K18) form the major hepatocyte cytoskeleton. We investigated the impact of genetic loss of either K8 or K18 on liver homeostasis under toxic stress with the hypothesis that K8 and K18 exert different functions. krt8⁻/⁻ and krt18⁻/⁻ mice crossed into the same 129-ola genetic background were treated by acute and chronic administration of 3,5-diethoxy-carbonyl-1,4-dihydrocollidine...

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PMID: 22449798
DOI: 10.1038/labinvest.2012.49

Genes

DDC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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