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Article

Keratin 18 overexpression but not phosphorylation or filament organization blocks mouse Mallory body formation.

Hepatology (Baltimore, Md.) - 1 Jan 2007

Harada Masaru, Strnad Pavel, Resurreccion Evelyn Z, Ku Nam-On, Omary M Bishr

Abstract excerpt

UNLABELLED: Several human liver diseases are associated with formation of Mallory body (MB) inclusions. These hepatocyte cytoplasmic deposits are composed primarily of hyperphosphorylated keratins 8 and 18 (K8/K18). Feeding a 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC)-containing diet is a well-established mouse model of MBs. K8 overexpression, and K8-null or K18-null mouse models, indicate that a...

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Source

Identifiers

PMID: 17187412
DOI: 10.1002/hep.21471

Genes

DDC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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