Article

A single point mutation in the σ3 protein encoded by the reovirus S4 gene substantially attenuates the virulence of a highly myocarditic reassortant virus in neonatal mice

2026-02-26

Abstract excerpt

<h4>ABSTRACT</h4> Viral myocarditis is a major cause of heart damage, sudden death, and heart failure. Some strains of Mammalian Orthoreoviruses (REOV) cause myocarditis in newborn mice. This study examines the role of the REOV σ3 protein, encoded by the S4 gene, in modulating the virulence and myocarditic potential of a highly virulent T1L/T3DM2 reassortant virus that contains the M2 gene from the Type 3 Dearing...

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Literature Corpus work: 0c7a0a6d-d364-59dd-bfde-0c7f326621f7
DOI: 10.64898/2026.02.25.707952

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