Article
Nucleotide sequence of an attenuated mutant of coxsackievirus B3 compared with the cardiovirulent wildtype: assessment of candidate mutations by analysis of a revertant to cardiovirulence.
Clinical and diagnostic virology - 1 Apr 1998
Cameron-Wilson C L, Pandolfino Y A, Zhang H Y, Pozzeto B, Archard L C
Abstract excerpt
BACKGROUND: Coxsackievirus B3 (CVB3) causes myocarditis in the SWR (H2q) mouse model and persistence of CVB3 in myocardium disposes to the development of dilated cardiomyopathy. An attenuated strain of CVB3 has been isolated, sequenced and several candidate mutations for attenuation identified. D...
Topics
- Amino Acid Substitution
- Animals
- Cell Line
- Chlorocebus aethiops
- Coxsackievirus Infections
- Enterovirus B, Human
- Male
- Mice
- Mice, SCID
- Mutation
- Myocarditis
- RNA, Viral
- Vaccines, Attenuated
- Vero Cells
- Virulence