A mutation in the puff region of VP2 attenuates the myocarditic phenotype of an infectious cDNA of the Woodruff variant of coxsackievirus B3.

doi:10.1128/JVI.70.11.7811-7818.1996

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Article

A mutation in the puff region of VP2 attenuates the myocarditic phenotype of an infectious cDNA of the Woodruff variant of coxsackievirus B3.

Journal of virology - 1 Nov 1996

Knowlton K U, Jeon E S, Berkley N, Wessely R, Huber S

Abstract excerpt

Coxsackievirus B3 (CVB3) infections induce myocarditis in humans and mice. Little is known about the molecular characteristics of CVB3 that activate the cellular immunity responsible for cardiac inflammation. Previous experiments have identified an antibody escape mutant (H310A1) of a myocarditic...

Topics

Animals
Aspartic Acid
Base Sequence
COS Cells
Capsid
Capsid Proteins
Cloning, Molecular
Coxsackievirus Infections
DNA, Complementary
DNA, Viral
Enterovirus B, Human
Genetic Variation
HeLa Cells
Humans
Mice
Mice, Inbred BALB C
Molecular Sequence Data
Mutation

Source

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Identifiers

PMID: 8892902
DOI: 10.1128/JVI.70.11.7811-7818.1996
PMCID: PMC190851

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8892902-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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