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Article

Attenuation of coxsackievirus B3 by VP2 mutation and its application as a vaccine against virus-induced myocarditis and pancreatitis.

Vaccine - 18 Mar 2009

Park Jung-Hyun, Kim Dae-Sun, Cho Young-Joo, Kim Yeon-Jung, Jeong Soo-Young, Lee Seung-Min, Cho Seong-Joo, Yun Cheol-Won, Jo Inho, Nam Jae-Hwan

Abstract excerpt

Coxsackievirus B3 (CVB3) is a common agent of viral myocarditis, a major cause of sudden cardiac death, and ultimately dilated cardiomyopathy. However, there is no vaccine in clinical use. In this study, we identified the conserved amino acid sequences in the C-terminal region of the VP2 of the coxsackievirus B group and some echoviruses. The mutant virus, YYFF, with phenylalanines substituted for two tyrosines...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19168108
DOI: 10.1016/j.vaccine.2009.01.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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