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Article

Mechanosensitive pannexin-1 channels mediate microvascular metastatic cell survival.

Nature cell biology - 1 Jul 2015

Furlow Paul W, Zhang Steven, Soong T David, Halberg Nils, Goodarzi Hani, Mangrum Creed, Wu Y Gloria, Elemento Olivier, Tavazoie Sohail F

Abstract excerpt

During metastatic progression, circulating cancer cells become lodged within the microvasculature of end organs, where most die from mechanical deformation. Although this phenomenon was first described over a half-century ago, the mechanisms enabling certain cells to survive this metastasis-suppressive barrier remain unknown. By applying whole-transcriptome RNA-sequencing technology to isogenic cancer cells of...

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Identifiers

PMID: 26098574
DOI: 10.1038/ncb3194
PMCID: PMC5310712

Genes

PANX1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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