Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Pannexin1 membrane channel: distinct conformations and functions.

FEBS letters - 1 Oct 2018

Dahl Gerhard

Abstract excerpt

The Pannexin1 (Panx1) membrane channel responds to different stimuli with distinct channel conformations. Most stimuli induce a large cation- and ATP-permeable conformation, hence Panx1 is involved in many physiological processes entailing purinergic signaling. For example, oxygen delivery in the peripheral circulatory system is regulated by ATP released from red blood cells and endothelial cells through Panx1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphate
Share to Caspase 3
Share to Connexins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ion Channels

Share to Models, Molecular

Share to Nerve Tissue Proteins

Share to Protein Conformation

Share to Signal Transduction

Source

Identifiers

PMID: 29802622
DOI: 10.1002/1873-3468.13115

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Pannexin1 membrane channel: distinct conformations and functions.PMID 29802622Read ↗

Structures of human pannexin 1 reveal ion pathways and mechanism of gating.Semantic proximity Read ↗

Pannexin-1 is blocked by its C-terminus through a delocalized non-specific interaction surface.Semantic proximity Read ↗

Differential activation of mouse and human Panx1 channel variantsSemantic proximity Read ↗

Mutational effects of Pannexin 1 R217H depend on the carboxyl-terminus.Semantic proximity Read ↗

A metastasis-associated pannexin-1 mutant (Panx11-89) forms a minimalist ATP release channel.Semantic proximity Read ↗

A Germline Variant in the PANX1 Gene Has Reduced Channel Function and Is Associated with Multisystem DysfunctionSemantic proximity Read ↗

Structural basis of ATP release and ion selectivity in Pannexin1 channelsSemantic proximity Read ↗

Endothelial pannexin 1 channels control inflammation by regulating intracellular calciumSemantic proximity Read ↗

Pharmacological characterization of pannexin-1 currents expressed in mammalian cells.Semantic proximity Read ↗

Mechanosensitive pannexin-1 channels mediate microvascular metastatic cell survival.Semantic proximity Read ↗

Pannexin 2 restrains ER stress-induced Ca <sup>2+</sup> dysregulation and inflammatory cardiomyocyte deathSemantic proximity Read ↗

A permeant regulating its permeation pore: inhibition of pannexin 1 channels by ATP.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.