Article

Cells in the Polyaneuploid Cancer Cell (PACC) state have increased metastatic potential

2022-09-19

Abstract excerpt

Although metastasis is the leading cause of cancer deaths, it is quite rare at the cellular level. Only a rare subset of cancer cells (∼1 in 1.5 billion) can complete the entire metastatic cascade: invasion, intravasation, survival in the circulation, extravasation, and colonization (i.e. are metastasis competent). We propose that cells engaging a Polyaneuploid Cancer Cell (PACC) phenotype are metastasis competent...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 59776652-17fc-5e22-9506-652d2e065303
DOI: 10.1101/2022.09.16.508155

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cells in the Polyaneuploid Cancer Cell (PACC) state have increased metastatic potentialDOI 10.1101/2022.09.16.508155Read

Cells in the Polyaneuploid Cancer Cell State are Pro-MetastaticSemantic proximity Read

Contributions of the distinct biophysical phenotype of polyploidal giant cancer cells to cancer progression.Semantic proximity Read

Poly‐aneuploid cancer cells promote evolvability, generating lethal cancerSemantic proximity Read

Dysregulation in Actin Cytoskeletal Organization Drives Increased Stiffness and Migratory Persistence in Polyploidal Giant Cancer CellsSemantic proximity Read

Cancer cell mechanobiology: a new frontier for cancer researchSemantic proximity Read

Understanding Polyploid Giant Cancer Cells: From Molecular Mechanisms to Clinical ImplicationsSemantic proximity Read

Deleterious Mechanical Deformation Selects Mechanoresilient Cancer Cells with Enhanced Proliferation and Chemoresistance.Semantic proximity Read

Trading in your spindles for blebs: the amoeboid tumor cell phenotype in prostate cancer.Semantic proximity Read

TMPO promotes cellular dissemination and metastasis in circulating tumor cellsSemantic proximity Read

Prostate cancer associated fibroblasts have distinct morphomechanical features that are associated with patient outcomeSemantic proximity Read

Nanoprotrusion enlargement conducts cytocapsular tube elongation along the path of least resistance for metastasis initiationSemantic proximity Read

Contacts with Macrophages Promote an Aggressive Nanomechanical Phenotype of Circulating Tumor Cells in Prostate Cancer.Semantic proximity Read