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Article

A metastasis-associated pannexin-1 mutant (Panx11-89) forms a minimalist ATP release channel.

The FEBS journal - 1 Jul 2025

Wang Junjie, Levi Noah J, Diaz-Solares Maykelis, Mim Carsten, Dahl Gerhard, Barro-Soria Rene

Abstract excerpt

A truncated form of the ATP release channel pannexin 1 (Panx1), Panx11-89, is enriched in metastatic breast cancer cells and has been proposed to mediate metastatic cell survival by increasing ATP release through mechanosensitive Panx1 channels. However, whether Panx11-89 on its own [without the presence of wild-type Panx1 (wtPanx1)] mediates ATP release has not been tested. Here, we show that Panx11-89 by itself...

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Identifiers

PMID: 40087867
DOI: 10.1111/febs.70060
PMCID: PMC12220848

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