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Polyploidy of MDA-MB-231 cells drives increased extravasation with enhanced cell-matrix adhesion

29 Jan 2025

Abstract excerpt

Metastasis, the leading cause of cancer-related deaths, involves a complex cascade of events, including extravasation. Despite extensive research into metastasis, the mechanisms underlying extravasation remain unclear. Molecular targeted therapies have advanced cancer treatment, yet their efficacy is limited, prompting exploration into novel therapeutic targets. Here, we showed the association of polyploidy in...

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PMID: 39974511
DOI: 10.1063/5.0233329

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