Article
Compression drives diverse transcriptomic and phenotypic adaptations in melanoma.
Proceedings of the National Academy of Sciences of the United States of America - 26 Sept 2023
Zhang Xingjian, Shi Xin, Zhang Dingyao, Gong Xiangyu, Wen Zhang, Demandel Israel, Zhang Junqi, Rossello-Martinez Alejandro, Chan Trevor J, Mak Michael
Abstract excerpt
Physical forces are prominent during tumor progression. However, it is still unclear how they impact and drive the diverse phenotypes found in cancer. Here, we apply an integrative approach to investigate the impact of compression on melanoma cells. We apply bioinformatics to screen for the most significant compression-induced transcriptomic changes and investigate phenotypic responses. We show that...
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