Article

Mechanical compression reprograms cell states associated with patient survival and therapy response

2026-04-01

Abstract excerpt

<title>Abstract</title> <p>Precision oncology frameworks primarily rely on tumor-intrinsic molecular features to guide therapeutic decision-making, yet the contribution of mechanical forces within the tumor microenvironment remains poorly defined. Here, we investigate how compressive stress, a fundamental mechanical force arising during tumor growth, reshapes tumor cell states and modulates clinically relevant th...

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Identifiers and source

Literature Corpus work: 8ff0e35d-1033-5686-a199-bb1e2bf88c84
DOI: 10.21203/rs.3.rs-9276682/v1

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