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Deleterious Mechanical Deformation Selects Mechanoresilient Cancer Cells with Enhanced Proliferation and Chemoresistance.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Aug 2023

Jiang Kuan, Lim Su Bin, Xiao Jingwei, Jokhun Doorgesh Sharma, Shang Menglin, Song Xiao, Zhang Pan, Liang Lanfeng, Low Boon Chuan, Shivashankar G V, Lim Chwee Teck

Abstract excerpt

Cancer cells in secondary tumors are found to form metastases more efficiently as compared to their primary tumor counterparts. This is partially due to the unfavorable microenvironments encountered by metastasizing cancer cells that result in the survival of a more metastatic phenotype from the original population. However, the role of deleterious mechanical stresses in this change of metastatic potential is...

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PMID: 37218524
DOI: 10.1002/advs.202201663
PMCID: PMC10401173

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