Article

Structural basis of ATP release and ion selectivity in Pannexin1 channels

2025-02-20

Abstract excerpt

<h4>Summary</h4> This study investigated the structural basis of adenosine triphosphate (ATP) release and ion selectivity by Pannexin1 (Panx1). The microinjection of active SRC tyrosine kinase increased Panx1-mediated currents in Panx1-expressing oocytes. Furthermore, a mutation mimicking phosphorylation at Y308 turned Panx1 into a constitutively open ATP-releasing channel with broad ion permeability. Cryogenic e...

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Literature Corpus work: 1e361c9d-5f41-5169-8a45-7f18c4d3e4ac
DOI: 10.1101/2025.02.17.638584

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