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Article

Calpain-Dependent ErbB4 Cleavage Is Involved in Brain Ischemia-Induced Neuronal Death.

Molecular neurobiology - 1 May 2016

Lu Ying-mei, Gao Yin-ping, Tao Rong-rong, Liao Mei-hua, Huang Ji-yun, Wu Gang, Han Feng, Li Xiao-ming

Abstract excerpt

Disturbance of neuregulin-1β/ErbB4 signaling is considered to be associated with brain ischemia, but the mechanisms of this disruption are largely unknown. In the present study, we provide evidence that degradation of ErbB4 is involved in neuronal cell death in response to ischemia. Our data showed that the application of neuregulin-1β provided significant protection against oxygen-glucose deprivation...

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Source

Identifiers

PMID: 26093380
DOI: 10.1007/s12035-015-9275-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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