Article
Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) Promotes Angiogenesis and Ischemia-Induced Neovascularization Via NADPH Oxidase 4 (NOX4) and Nitric Oxide-Dependent Mechanisms.
Journal of the American Heart Association - 16 Nov 2015
Di Bartolo Belinda Ann, Cartland Siân Peta, Prado-Lourenco Leonel, Griffith Thomas Scott, Gentile Carmine, Ravindran Jayant, Azahri Nor Saadah Muhammad, Thai Thuan, Yeung Amanda Wing Shee, Thomas Shane Ross, Kavurma Mary Meltem
Abstract excerpt
BACKGROUND: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has the ability to inhibit angiogenesis by inducing endothelial cell death, as well as being able to promote pro-angiogenic activity in vitro. These seemingly opposite effects make its role in ischemic disease unclear. Using Trail(-/-) and wildtype mice, we sought to determine the role of TRAIL in angiogenesis and neovascularization...
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