Article

Targeting PFKFB3 alleviates cerebral ischemia-reperfusion injury in mice

2019-01-11

Abstract excerpt

The glycolytic rate in neurons is low in order to allow glucose to be metabolized through the pentose-phosphate pathway (PPP), which regenerates NADPH to preserve the glutathione redox status and survival. This is controlled by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3), the pro-glycolytic enzyme that forms fructose-2,6-bisphosphate, a powerful allosteric activator of 6-phosphofructo-1-kinase....

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Literature Corpus work: 6342efb4-086b-56f6-9681-eb1b7e36a785
DOI: 10.1101/518092

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