Tyrosine Phosphorylation of the Kv2.1 Channel Contributes to Injury in Brain Ischemia.

doi:10.3390/ijms21249538

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Article

Tyrosine Phosphorylation of the Kv2.1 Channel Contributes to Injury in Brain Ischemia.

International journal of molecular sciences - 15 Dec 2020

Song Min-Young, Hwang Ji Yeon, Bae Eun Ji, Kim Saesbyeol, Kang Hye-Min, Kim Yong Jun, Park Chan, Park Kang-Sik

Abstract excerpt

In brain ischemia, oxidative stress induces neuronal apoptosis, which is mediated by increased activity of the voltage-gated K+ channel Kv2.1 and results in an efflux of intracellular K+. The molecular mechanisms underlying the regulation of Kv2.1 and its activity during brain ischemia are not yet fully understood. Here this study provides evidence that oxidant-induced apoptosis resulting from brain ischemia...

Topics

2,2'-Dipyridyl
Animals
Apoptosis
Brain Ischemia
Cell Survival
Disulfides
HEK293 Cells
Humans
Immunohistochemistry
Male
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred C57BL

Mutation

Neurons

Oxidative Stress

Phosphorylation

Poly (ADP-Ribose) Polymerase-1

Rats

Source

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Identifiers

PMID: 33333928
DOI: 10.3390/ijms21249538
PMCID: PMC7765428

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