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Article

NDRG4 protein-deficient mice exhibit spatial learning deficits and vulnerabilities to cerebral ischemia.

The Journal of biological chemistry - 22 Jul 2011

Yamamoto Hitomi, Kokame Koichi, Okuda Tomohiko, Nakajo Yukako, Yanamoto Hiroji, Miyata Toshiyuki

Abstract excerpt

The N-myc downstream-regulated gene (NDRG) family consists of four related proteins, NDRG1-NDRG4, in mammals. We previously generated NDRG1-deficient mice that were unable to maintain myelin sheaths in peripheral nerves. This condition was consistent with human hereditary motor and sensory neuropathy, Charcot-Marie-Tooth disease type 4D, caused by a nonsense mutation of NDRG1. In contrast, the effects of genetic...

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Source

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Identifiers

PMID: 21636852
DOI: 10.1074/jbc.M111.256446
PMCID: PMC3138246

Genes

NDRG4
BDNF
NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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