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Article

BID mediates neuronal cell death after oxygen/ glucose deprivation and focal cerebral ischemia.

Proceedings of the National Academy of Sciences of the United States of America - 18 Dec 2001

Plesnila N, Zinkel S, Le D A, Amin-Hanjani S, Wu Y, Qiu J, Chiarugi A, Thomas S S, Kohane D S, Korsmeyer S J, Moskowitz M A

Abstract excerpt

Mitochondria and cytochrome c release play a role in the death of neurons and glia after cerebral ischemia. In the present study, we investigated whether BID, a proapoptotic promoter of cytochrome c release and caspase 8 substrate, was expressed in brain, activated after an ischemic insult in vivo and in vitro, and contributed to ischemic cell death. We detected BID in the cytosol of mouse brain and primary...

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Identifiers

PMID: 11742085
DOI: 10.1073/pnas.261323298
PMCID: PMC65027

Genes

BID

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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