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Protein Kinase C δ Mediates Cerebral Reperfusion Injury<i>In Vivo</i>

4 Aug 2004

Abstract excerpt

Protein kinase C (PKC) has been implicated in mediating ischemic and reperfusion damage in multiple organs. However, conflicting reports exist on the role of individual PKC isozymes in cerebral ischemic injury. Using a peptide inhibitor selective for deltaPKC, deltaV1-1, we found that deltaPKC inhibition reduced cellular injury in a rat hippocampal slice model of cerebral ischemia [oxygen-glucose deprivation...

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Share to Cardiac Ischemia and Reperfusion
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PMID: 15295022
DOI: 10.1523/jneurosci.4474-03.2004

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