Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

APOBEC Enzymes: Mutagenic Fuel for Cancer Evolution and Heterogeneity.

Cancer discovery - 1 Jul 2015

Swanton Charles, McGranahan Nicholas, Starrett Gabriel J, Harris Reuben S

Abstract excerpt

UNLABELLED: Deep sequencing technologies are revealing the complexities of cancer evolution, casting light on mutational processes fueling tumor adaptation, immune escape, and treatment resistance. Understanding mechanisms driving cancer diversity is a critical step toward developing strategies to attenuate tumor evolution and adaptation. One emerging mechanism fueling tumor diversity and subclonal evolution is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to APOBEC Deaminases
Share to Cytidine Deaminase
Share to Cytosine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytosine Deaminase

Share to Deamination

Share to Evolution, Molecular

Share to Genetic Heterogeneity

Share to Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 26091828
DOI: 10.1158/2159-8290.CD-15-0344
PMCID: PMC4497973

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

APOBEC Enzymes: Mutagenic Fuel for Cancer Evolution and Heterogeneity.PMID 26091828Read ↗

APOBEC3-mediated mutagenesis in cancer: causes, clinical significance and therapeutic potential.Semantic proximity Read ↗

The cytidine deaminase APOBEC3G drives cancer mutagenesis and clonal evolution in bladder cancerSemantic proximity Read ↗

Addressing the benefits of inhibiting APOBEC3-dependent mutagenesis in cancer.Semantic proximity Read ↗

APOBEC-Induced Mutagenesis in Cancer.Semantic proximity Read ↗

APOBEC3B, a molecular driver of mutagenesis in human cancersSemantic proximity Read ↗

Mechanisms of APOBEC3 mutagenesis in human cancer cellsSemantic proximity Read ↗

Mutational heterogeneity in human cancers: origin and consequences.Semantic proximity Read ↗

APOBEC in breast cancer: a dual player in tumor evolution and therapeutic responseSemantic proximity Read ↗

Biological and therapeutic impact of intratumor heterogeneity in cancer evolution.Semantic proximity Read ↗

An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers.Semantic proximity Read ↗

The APOBEC3A deaminase drives episodic mutagenesis in cancer cellsSemantic proximity Read ↗

The APOBEC3A deaminase drives episodic mutagenesis in cancer cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.