Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutational heterogeneity in human cancers: origin and consequences.

Annual review of pathology - 1 Jan 2010

Salk Jesse J, Fox Edward J, Loeb Lawrence A

Abstract excerpt

Cancer recapitulates Darwinian evolution. Mutations acquired during life that provide cells with a growth or survival advantage will preferentially multiply to form a tumor. As a result of The Cancer Genome Atlas Project, we have gathered detailed information on the nucleotide sequence changes in a number of human cancers. The sources of mutations in cancer are diverse, and the complexity of those found to be...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Evolution, Molecular
Share to Cancer Genomics and Diagnostics
Share to DNA, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic factors in colorectal cancer

Share to Human Genome Project

Share to Mutation

Share to Neoplasms

Share to Sequence Analysis, DNA

Source

Open in PubMed Open full text

Identifiers

PMID: 19743960
DOI: 10.1146/annurev-pathol-121808-102113
PMCID: PMC3375045

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutational heterogeneity in human cancers: origin and consequences.PMID 19743960Read ↗

Implications of genetic heterogeneity in cancer.Semantic proximity Read ↗

Somatic mutation in cancer and normal cells.Semantic proximity Read ↗

Patterns of somatic mutation in human cancer genomes.Semantic proximity Read ↗

A new branch on the tree: next-generation sequencing in the study of cancer evolution.Semantic proximity Read ↗

Unraveling the Drivers of Tumorigenesis in the Context of Evolution: Theoretical Models and Bioinformatics Tools.Semantic proximity Read ↗

Cells with cancer‐associated mutations overtake our tissues as we ageSemantic proximity Read ↗

Translating insights into tumor evolution to clinical practice: promises and challengesSemantic proximity Read ↗

Somatic variation in normal tissues: friend or foe of cancer early detection?Semantic proximity Read ↗

Multiple mutations and cancer.Semantic proximity Read ↗

Somatic variation and cancer: therapies lost in the mix.Semantic proximity Read ↗

Hypermutation in human cancer genomes: footprints and mechanisms.Semantic proximity Read ↗

Catalogue, cause, complexity and cure; the many uses of cancer genome sequence.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.