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Article

Biological and therapeutic impact of intratumor heterogeneity in cancer evolution.

Cancer cell - 12 Jan 2015

McGranahan Nicholas, Swanton Charles

Abstract excerpt

Precision medicine requires an understanding of cancer genes and mutational processes, as well as an appreciation of the extent to which these are found heterogeneously in cancer cells during tumor evolution. Here, we explore the processes shaping the cancer genome, placing these within the context of tumor evolution and their impact on intratumor heterogeneity and drug development. We review evidence for...

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Identifiers

PMID: 25584892
DOI: 10.1016/j.ccell.2014.12.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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