Article
Screening strategy to generate cell specific recombination: a case report with the RIP-Cre mice.
Transgenic research - 1 Oct 2015
Spinelli Valeria, Martin Céline, Dorchies Emilie, Vallez Emmanuelle, Dehondt Hélène, Trabelsi Mohamed-Sami, Tailleux Anne, Caron Sandrine, Staels Bart
Abstract excerpt
Conditional gene knockout technology is a powerful tool to study the function of a gene in a specific tissue, organ or cell lineage. The most commonly used procedure applies the Cre-LoxP strategy, where the choice of the Cre driver promoter is critical to determine the efficiency and specificity of the system. However, a considered choice of an appropriate promoter does not always protect against the risk of...
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