[Modification of gene targeting method for functional analysis of the target gene in vivo].

Abstract excerpt

Gene targeting in ES cells is a powerful tool to generate mice bearing predesigned mutations in the germ line. However, these mice carrying such constitutional mutations are often lethal and, therefore, we cannot study other functional aspects of the gene at later stages or in particular tissues....

Topics

• Animals
• Blastocyst
• Cells, Cultured
• Gene Targeting
• Genes, APC
• Integrases
• Mice
• Mice, Transgenic
• Mutation
• Viral Proteins