Article
Generating mouse lines for lineage tracing and knockout studies.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2014
Kraus Petra, Sivakamasundari V, Xing Xing, Lufkin Thomas
Abstract excerpt
In 2007 Capecchi, Evans, and Smithies received the Nobel Prize in recognition for discovering the principles for introducing specific gene modifications in mice via embryonic stem cells, a technology, which has revolutionized the field of biomedical science allowing for the generation of genetically engineered animals. Here we describe detailed protocols based on and developed from these ground-breaking...
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