Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gene targeting in mice: a review.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2013

Bouabe Hicham, Okkenhaug Klaus

Abstract excerpt

The ability to introduce DNA sequences (e.g., genes) of interest into the germline genome has rendered the mouse a powerful and indispensable experimental model in fundamental and medical research. The DNA sequences can be integrated into the genome randomly or into a specific locus by homologous recombination, in order to: (1) delete or insert mutations into genes of interest to determine their function, (2)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Embryonic Stem Cells
Share to Gene Targeting
Share to Genes, Reporter

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Vectors

Share to Homologous Recombination

Share to RNA, Untranslated

Share to Transgenes

Share to Viruses

Source

Open in PubMed Open full text

Identifiers

PMID: 23996268
DOI: 10.1007/978-1-62703-601-6_23
PMCID: PMC4524968

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gene targeting in mice: a review.PMID 23996268Read ↗

Gene targeting in the mouse.Semantic proximity Read ↗

Overview of gene targeting by homologous recombination.Semantic proximity Read ↗

Introduction: Strategies for developing genetically modified mice.Semantic proximity Read ↗

Genome engineering via homologous recombination in mouse embryonic stem (ES) cells: an amazingly versatile tool for the study of mammalian biology.Semantic proximity Read ↗

Ten years of gene targeting: targeted mouse mutants, from vector design to phenotype analysis.Semantic proximity Read ↗

Mammalian genome targeting using site-specific recombinases.Semantic proximity Read ↗

Modifying the mouse: design and desire.Semantic proximity Read ↗

Strategies to achieve conditional gene mutation in mice.Semantic proximity Read ↗

Gene trap mutagenesis.Semantic proximity Read ↗

Technical approaches for mouse models of human disease.Semantic proximity Read ↗

Beyond 'knock-out' mice: new perspectives for the programmed modification of the mammalian genome.Semantic proximity Read ↗

Knock-in approaches.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.