Article
Down-regulation of Stathmin Is Required for the Phenotypic Changes and Classical Activation of Macrophages.
The Journal of biological chemistry - 31 Jul 2015
Xu Kewei, Harrison Rene E
Abstract excerpt
Macrophages are important cells of innate immunity with specialized capacity for recognition and elimination of pathogens and presentation of antigens to lymphocytes for adaptive immunity. Macrophages become activated upon exposure to pro-inflammatory cytokines and pathogenic stimuli. Classical activation of macrophages with interferon-γ (IFNγ) and lipopolysaccharide (LPS) triggers a wide range of signaling...
Topics
- Animals
- CDC2 Protein Kinase
- Cell Line
- Cell Shape
- Down-Regulation
- Interferon-gamma
- Lipopolysaccharides
- Macrophage Activation
- Macrophages
- Mice
- Microtubules
- Phagocytosis
- Phenotype
- Proteasome Endopeptidase Complex
- Protein Stability
- Receptors, Complement
- Sheep, Domestic
- Stathmin