Wiskott-Aldrich Syndrome Protein Regulates Nucleolar Organization and Function in Innate Immune Response

Abstract excerpt

<h4>ABSTRACT</h4> Wiskott-Aldrich syndrome (WAS) is a primary immunodeficiency disorder caused by the dysfunction of the WAS protein (WASP). Using an isogenic macrophage model derived from genome edited induced pluripotent stem cells we demonstrated that WASP functions in the nucleolus, which plays important roles in immune regulation. The absence of WASP resulted in smaller and misshapen nucleoli, decreased fibr...

Topics

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• Cell Adhesion Molecules Research
• Cellular Mechanics and Interactions
• Cellular transport and secretion
• Immunologic Deficiency Syndromes
• Mutation
• Thrombocytopenia
• Wiskott-Aldrich Syndrome
• Wiskott-Aldrich Syndrome Protein

Identifiers and source

Literature Corpus work

c38ac5de-c5cb-50ee-8641-b0252dc41fcd

DOI

10.1101/2023.08.15.553387