Article

Phactr4 influences macrophage lamellipodial structure and dynamics through Arp2/3 complex and Ezrin regulation

2025-05-14

Abstract excerpt

Dynamic cycles of actin remodeling drive membrane protrusion and retraction events essential for macrophage function. Phosphoregulation of actin-associated proteins plays a key role, but the factors that determine the spatiotemporal balance between kinases and phosphatases is less well understood in this context. Here, we identify the Protein Phosphatase 1 (PP1)-binding protein Phactr4 as a critical regulator of c...

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Literature Corpus work: f75e2765-6419-5bb2-bd91-22d4fe8494e1
DOI: 10.1101/2025.05.13.653717

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