Article

Age-dependent Dysferlin Accumulation in Macrophages Promotes STAT1 Activation via Calcium Influx, Impairing Myogenesis

2025-10-04

Abstract excerpt

DYSF functions as a regulator of Ca²⁺ in the skeletal muscle and facilitates muscle repair following injury. It is also highly expressed in monocytes and macrophages and related to inflammation, immune regulation, and the mononuclear phagocyte system. Macrophages are pivotal in driving myogenesis, and specific cytokine-induced macrophage differentiation plays a role in maintaining skeletal muscle during disease an...

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Literature Corpus work: d2fcf903-a6af-56b4-94a1-40712f48c7ec
DOI: 10.1101/2025.10.02.679938

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