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SIRT7 remodels the cytoskeleton via RAC1 to enhance host resistance to Mycobacterium tuberculosis

17 Sept 2024

Abstract excerpt

ABSTRACT Phagocytosis of Mycobacterium tuberculosis ( Mtb ) followed by its integration into the matured lysosome is critical in the host defense against tuberculosis. How Mtb escapes this immune attack remains elusive. In this study, we unveiled a novel regulatory mechanism by which SIRT7 regulates cytoskeletal remodeling by modulating RAC1 activation. We discovered that SIRT7 expression was significantly...

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PMID: 39287444
DOI: 10.1128/mbio.00756-24

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