Article

Blockage of Lamin-A/C loss diminishes the pro-inflammatory macrophage response

2022-02-22

Abstract excerpt

Mutations and defects in nuclear lamins can cause major pathologies in affected tissues. Recent studies have also established potential links between lamins, inflammation, and inflammatory diseases but the underlying molecular mechanisms are unknown. We now report that pro-inflammatory activation of macrophages reduces levels of Lamin-A/C to augment pro-inflammatory gene expression and cytokine secretion. We show...

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Literature Corpus work: 4f86332b-2988-5e45-9ac6-d5ae399bee69
DOI: 10.1101/2022.02.22.481454

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