Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Defective Hfp-dependent transcriptional repression of dMYC is fundamental to tissue overgrowth in Drosophila XPB models.

Nature communications - 15 Jun 2015

Lee Jue Er Amanda, Mitchell Naomi C, Zaytseva Olga, Chahal Arjun, Mendis Peter, Cartier-Michaud Amandine, Parsons Linda M, Poortinga Gretchen, Levens David L, Hannan Ross D, Quinn Leonie M

Abstract excerpt

Nucleotide excision DNA repair (NER) pathway mutations cause neurodegenerative and progeroid disorders (xeroderma pigmentosum (XP), Cockayne syndrome (CS) and trichothiodystrophy (TTD)), which are inexplicably associated with (XP) or without (CS/TTD) cancer. Moreover, cancer progression occurs in certain patients, but not others, with similar C-terminal mutations in the XPB helicase subunit of transcription and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Proliferation
Share to Chromatin Immunoprecipitation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Helicases

Share to Drosophila melanogaster

Share to Drosophila Proteins

Share to Guanine Nucleotide Exchange Factors

Share to Immunohistochemistry

Share to Xeroderma Pigmentosum

Source

Open in PubMed Open full text

Identifiers

PMID: 26074141
DOI: 10.1038/ncomms8404
PMCID: PMC7720677

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Defective Hfp-dependent transcriptional repression of dMYC is fundamental to tissue overgrowth in Drosophila XPB models.PMID 26074141Read ↗

DNA repair and transcriptional effects of mutations in TFIIH in Drosophila development.Semantic proximity Read ↗

A Drosophila XPD model links cell cycle coordination with neuro-development and suggests links to cancer.Semantic proximity Read ↗

<i>C. elegans</i> TFIIH subunit GTF-2H5/TTDA is a non-essential transcription factor indispensable for DNA repairSemantic proximity Read ↗

Hairless and the polyamine putrescine form a negative regulatory loop in the epidermis.Semantic proximity Read ↗

Drosophila as a Model Organism to Understand the Effects during Development of TFIIH-Related Human Diseases.Semantic proximity Read ↗

Defective interplay of activators and repressors with TFIH in xeroderma pigmentosum.Semantic proximity Read ↗

Molecular characterization of mutant alleles of the DNA repair/basal transcription factor haywire/ERCC3 in Drosophila.Semantic proximity Read ↗

RNA polymerase II 140wimp mutant and mutations in the TFIIH subunit XPB differentially affect homeotic gene expression in Drosophila.Semantic proximity Read ↗

Mouse model for the DNA repair/basal transcription disorder trichothiodystrophy reveals cancer predisposition.Semantic proximity Read ↗

Genetic and Molecular Interactions between HΔCT, a Novel Allele of the Notch Antagonist Hairless, and the Histone Chaperone Asf1 in Drosophila melanogaster.Semantic proximity Read ↗

Drosophila Hfp negatively regulates dmyc and stg to inhibit cell proliferation.Semantic proximity Read ↗

Developmental function of Elf-1: an essential transcription factor during embryogenesis in Drosophila.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.