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Article

Genetic and Molecular Interactions between HΔCT, a Novel Allele of the Notch Antagonist Hairless, and the Histone Chaperone Asf1 in Drosophila melanogaster.

Genes - 13 Jan 2023

Maier Dieter, Bauer Milena, Boger Mike, Sanchez Jimenez Anna, Yuan Zhenyu, Fechner Johannes, Scharpf Janika, Kovall Rhett A, Preiss Anette, Nagel Anja C

Abstract excerpt

Cellular differentiation relies on the highly conserved Notch signaling pathway. Notch activity induces gene expression changes that are highly sensitive to chromatin landscape. We address Notch gene regulation using Drosophila as a model, focusing on the genetic and molecular interactions between the Notch antagonist Hairless and the histone chaperone Asf1. Earlier work implied that Asf1 promotes the silencing...

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Identifiers

PMID: 36672946
DOI: 10.3390/genes14010205
PMCID: PMC9858708

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Genetic and Molecular Interactions between HΔCT, a Novel Allele of the Notch Antagonist Hairless, and the Histone Chaperone Asf1 in Drosophila melanogaster.PMID 36672946Read ↗

Gene-specific targeting of the histone chaperone asf1 to mediate silencing.Semantic proximity Read ↗

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Hairless-binding deficient Suppressor of Hairless alleles reveal Su(H) protein levels are dependent on complex formation with Hairless.Semantic proximity Read ↗

Gain of function notch phenotypes associated with ectopic expression of the Su(H) C-terminal domain illustrate separability of Notch and hairless-mediated activities.Semantic proximity Read ↗

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Membrane-Anchored Hairless Protein Restrains Notch Signaling Activity.Semantic proximity Read ↗

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