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Article

Drosophila Hfp negatively regulates dmyc and stg to inhibit cell proliferation.

Development (Cambridge, England) - 1 Mar 2004

Quinn Leonie M, Dickins Ross A, Coombe Michelle, Hime Gary R, Bowtell David D L, Richardson Helena

Abstract excerpt

Mammalian FIR has dual roles in pre-mRNA splicing and in negative transcriptional control of Myc. Here we show that Half pint (Hfp), the Drosophila orthologue of FIR, inhibits cell proliferation in Drosophila. We find that Hfp overexpression potently inhibits G1/S progression, while hfp mutants display ectopic cell cycles. Hfp negatively regulates dmyc expression and function, as reducing the dose of hfp...

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Identifiers

PMID: 14993190
DOI: 10.1242/dev.01019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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