Article
Hairless and the polyamine putrescine form a negative regulatory loop in the epidermis.
Experimental dermatology - 1 Oct 2013
Luke Courtney T, Casta Alexandre, Kim Hyunmi, Christiano Angela M
Abstract excerpt
Hairless (HR) is a nuclear protein with corepressor activity that is highly expressed in the skin and hair follicle. Mutations in Hairless lead to hair loss accompanied by the appearance of papules (atrichia with papular lesions), and similar phenotypes appear when the key polyamine enzymes ornithine decarboxylase (ODC) and spermidine/spermine N(1) -acetyltransferase (SSAT) are overexpressed. Both ODC and SSAT...
Topics
- 3T3 Cells
- Animals
- Basic Helix-Loop-Helix Transcription Factors
- Epidermis
- Gene Expression Regulation
- Hair
- Keratinocytes
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Mutation