Article
RNA polymerase II 140wimp mutant and mutations in the TFIIH subunit XPB differentially affect homeotic gene expression in Drosophila.
Genesis (New York, N.Y. : 2000) - 1 Sept 2004
Gutiérrez Luis, Merino Carlos, Vázquez Martha, Reynaud Enrique, Zurita Mario
Abstract excerpt
Mutations in the XPB and XPD helicases of the DNA repair/transcription factor TFIIH are involved in several human genetic disorders. An unanswered problem concerning the complexity of the phenotype-genotype relationship is why mutations in individual subunits of TFIIH produce specific phenotypes and not many others. In order to investigate this question we tested whether mutations in the Drosophila XPB homolog,...
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