Article
Defective interplay of activators and repressors with TFIH in xeroderma pigmentosum.
Cell - 9 Feb 2001
Liu J, Akoulitchev S, Weber A, Ge H, Chuikov S, Libutti D, Wang X W, Conaway J W, Harris C C, Conaway R C, Reinberg D, Levens D
Abstract excerpt
Inherited mutations of the TFIIH helicase subunits xeroderma pigmentosum (XP) B or XPD yield overlapping DNA repair and transcription syndromes. The high risk of cancer in these patients is not fully explained by the repair defect. The transcription defect is subtle and has proven more difficult to evaluate. Here, XPB and XPD mutations are shown to block transcription activation by the FUSE Binding Protein (FBP),...
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