Article

<i>C. elegans</i> TFIIH subunit GTF-2H5/TTDA is a non-essential transcription factor indispensable for DNA repair

2021-06-04

Abstract excerpt

The 10-subunit TFIIH complex is vital to both transcription initiation and nucleotide excision repair. Hereditary mutations in its smallest subunit, TTDA/GTF2H5, cause a photosensitive form of the rare developmental brittle hair disorder trichothiodystrophy (TTD). Some TTD features are thought to be caused by subtle transcription or gene expression defects. Strikingly, TTDA/GTF2H5 knockout mice are not viable, whi...

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Literature Corpus work: 836c0b99-9364-5246-863a-54ce6a25b822
DOI: 10.1101/2021.06.04.447037

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