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Article

Mouse model for the DNA repair/basal transcription disorder trichothiodystrophy reveals cancer predisposition.

Cancer research - 15 Jul 1999

de Boer J, van Steeg H, Berg R J, Garssen J, de Wit J, van Oostrum C T, Beems R B, van der Horst G T, van Kreijl C F, de Gruijl F R, Bootsma D, Hoeijmakers J H, Weeda G

Abstract excerpt

Patients with the nucleotide excision repair (NER) disorder xeroderma pigmentosum (XP) are highly predisposed to develop sunlight-induced skin cancer, in remarkable contrast to photosensitive NER-deficient trichothiodystrophy (TTD) patients carrying mutations in the same XPD gene. XPD encodes a h...

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Source

Identifiers

PMID: 10416615

Genes

XPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-10416615-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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