Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA repair and transcriptional effects of mutations in TFIIH in Drosophila development.

Molecular biology of the cell - 1 Sept 2002

Merino Carlos, Reynaud Enrique, Vázquez Martha, Zurita Mario

Abstract excerpt

Mutations in XPB and XPD TFIIH helicases have been related with three hereditary human disorders: xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy. The dual role of TFIIH in DNA repair and transcription makes it difficult to discern which of the mutant TFIIH phenotypes is due to defects in any of these different processes. We used haywire (hay), the Drosophila XPB homolog, to dissect this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Wings, Animal
Share to Cyclin-Dependent Kinases
Share to Nucleic Acid Hybridization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to TATA-Binding Protein Associated Factors

Share to Transcription Factor TFIID

Share to Transcription Factor TFIIH

Share to Transcription Factors, TFII

Share to Ultraviolet Rays

Source

Open in PubMed Open full text

Identifiers

PMID: 12221129
DOI: 10.1091/mbc.e02-02-0087
PMCID: PMC124156

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA repair and transcriptional effects of mutations in TFIIH in Drosophila development.PMID 12221129Read ↗

RNA polymerase II 140wimp mutant and mutations in the TFIIH subunit XPB differentially affect homeotic gene expression in Drosophila.Semantic proximity Read ↗

Drosophila as a Model Organism to Understand the Effects during Development of TFIIH-Related Human Diseases.Semantic proximity Read ↗

Analysis of Drosophila p8 and p52 mutants reveals distinct roles for the maintenance of TFIIH stability and male germ cell differentiation.Semantic proximity Read ↗

TFIIH: from transcription to clinicSemantic proximity Read ↗

Defective Hfp-dependent transcriptional repression of dMYC is fundamental to tissue overgrowth in Drosophila XPB models.Semantic proximity Read ↗

DNA repair and transcriptional deficiencies caused by mutations in the Drosophila p52 subunit of TFIIH generate developmental defects and chromosome fragility.Semantic proximity Read ↗

A Drosophila XPD model links cell cycle coordination with neuro-development and suggests links to cancer.Semantic proximity Read ↗

TFIIH is an elongation factor of RNA polymerase I.Semantic proximity Read ↗

A temperature-sensitive disorder in basal transcription and DNA repair in humans.Semantic proximity Read ↗

Investigations of CHD1 function in transcription and development of Drosophila melanogaster.Semantic proximity Read ↗

Defective interplay of activators and repressors with TFIH in xeroderma pigmentosum.Semantic proximity Read ↗

Molecular characterization and developmental expression of the TFIIH factor p62 gene from Drosophila melanogaster: effects on the UV light sensitivity of a p62 mutant fly.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.