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Article

Autophagy and inflammatory bowel disease: Association between variants of the autophagy-related IRGM gene and susceptibility to Crohn's disease.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver - 1 Sept 2015

Rufini Sara, Ciccacci Cinzia, Di Fusco Davide, Ruffa Alessandra, Pallone Francesco, Novelli Giuseppe, Biancone Livia, Borgiani Paola

Abstract excerpt

BACKGROUND: Crohn's disease and ulcerative colitis are inflammatory bowel diseases involving a genetically determined inappropriate mucosal immune response towards luminal antigens, including resident bacterial flora. Recent studies identified susceptibility genes involved in autophagy. AIMS: We analyzed known autophagic loci (IRGM, ULK1 and AMBRA1) previously described as associated with inflammatory bowel...

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Source

Identifiers

PMID: 26066377
DOI: 10.1016/j.dld.2015.05.012

Genes

IRGM
AMBRA1
ULK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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