Article
Role of autophagy and autophagy genes in inflammatory bowel disease.
Current topics in microbiology and immunology - 1 Jan 2009
Cadwell Ken, Stappenbeck Thaddeus S, Virgin Herbert W
Abstract excerpt
Polymorphisms associated with two genes in the autophagy pathway, ATG16L1 and IRGM1, have been implicated in susceptibility to Crohn's disease, an idiopathic inflammatory disease typically involving the gastrointestinal tract. The intestinal mucosa is a site of careful immune regulation where the epithelium and immune cells encounter pathogens as well as a robust and diverse population of indigenous microbes that...
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